Mayeso Atsopano a Hangzhou Akhazikitsa Chidziwitso Chatsopano Chopanga Pet Diagnostic - Canine ndi Feline Renal Function 3-in-1 Combo Test Kit
Hangzhou New-Test Biotechnology Co., Ltd yalengeza mwalamulo kukhazikitsidwa kwa zinthu ziwiri zatsopano zodziwira ziweto zomwe zakhala zikupanga kwakanthawi pamsika wapadziko lonse lapansi wa matenda amtundu wa ziweto: Canine/Feline renal function Triple Test Kit (Creatinine/SDMA/CysC Triple Test) (Mkuyu 1 ndi mkuyu. 2), zomwe zimabweretsa njira yatsopano komanso yolondola yowunikira zaumoyo wa ziweto ndi chithandizo.
Chithunzi 1 Canine aimpso ntchito katatu kayesero katatu Chithunzi 2 Feline aimpso ntchito katatu
Mu Okutobala 2022, New-Test Biotechnology Co., Ltd. inali yoyamba kukhazikitsa makina osanthula amtundu wa multichannel multiplex fluorescence immunoassay, NTIMM4 (m'badwo wachitatu, onani Chithunzi 3), ndipo mu 2024, njira yatsopano ya single-channel multiplex immunofluorescence. analyzer, NTIMM2 (m'badwo wachinayi, onani Chithunzi 4). Zida zaposachedwa za canine/feline aimpso 3-in-1 combo test kit imagwirizana ndi mitundu yonse iwiri.
Chithunzi 3 NTIMM4 Chithunzi 4 NTIMM2
Zokhazikika pakufufuza ndi chitukuko cha mamolekyu ang'onoang'ono kwa zaka zisanu ndi chimodzi, zatsopano zimayambitsidwa.
Kulondola kwa kuzindikira kwa mamolekyu ang'onoang'ono nthawi zonse kwakhala kovuta kuthana ndi kuyesa kwa POCT, komanso ndikuwongolera kafukufuku ndi chitukuko chomwe Nest-Test Bio yadzipereka kuyambira pomwe idakhazikitsidwa zaka 6 zapitazo. Kuzimitsa kwakuthupi ndi kuwola kwa zida zamtundu wa fulorosenti kumakhudza mwachindunji kulondola kwa zotsatira zowunikira ma molekyulu ang'onoang'ono. Ukadaulo wapadziko lapansi wosawerengeka wa nanocrystal, m'badwo wachinayi wa ma fluorescent nanomaterials opangidwa ndi New-Test, umadziwika kuti ndiwokhazikika kwambiri ma nanomaterials a fulorosenti pamsika, omwe ali ndi mwayi wothana ndi mawonekedwe akuzimitsa kuwala. Kuphatikizidwa ndi zaka zingapo zakukhathamiritsa kopitilira muyeso, zathetsa vuto lapadziko lonse lapansi losalondola bwino pakuyesa kwa ma molekyulu ang'onoang'ono a POCT. Kukankhira koyamba ndiko kuyesa kwa impso katatu. Imatsimikizira kulondola ndi kukhazikika kwa mamolekyu awiri ang'onoang'ono (creatinine & SDMA) zozindikiritsa zowunikira mkati mwa zaka ziwiri zovomerezeka.
“Mayeso amodzi amapezekanso, ndiye bwanji kupanga utatu wa aimpso”—Chiyambi cha kukula kwa utatu wa aimpso
Pakalipano, zizindikiro zodziwika bwino za ntchito ya impso ya agalu ndi amphaka zimaphatikizapo creatinine (CREA) ndi urea nitrogen mu biochemistry; CysC (cystatin C) ndi symmetric dimethylarginine (SDMA) mu zizindikiro chitetezo chokwanira, etc. Pakali pano, ambiri amakhulupirira kuti onse pamwamba - zizindikiro zotchulidwa amasefedwa kudzera glomerulus. Pamene kusefera kwa glomerular kumachepa chifukwa cha kuvulala kwa impso, zizindikirozi zimawunjikana m'magazi ndikuwonjezereka kwa ndende, motero zikuwonetsa kuwonongeka kwa aimpso. Bungwe la International Society for Research in Kidney Diseases (IRIS) limagawira kulephera kwa aimpso kwa amphaka m'magulu anayi kutengera mtengo wa creatinine (Giredi I, wamba kapena wofatsa: <1.6 mg/dL; Gulu II, mopyola: 1.6-2.8 mg / dL; Gawo lachitatu, lamphamvu: 2.8-5.0 mg / dL; mg/dL).
Kuwonongeka kwa aimpso kwa agalu kumagawika m'magulu anayi (Giredi I, yachibadwa kapena yofatsa: <1.4 mg/dL: Gulu II, pang'onopang'ono: 1.4-2.0 mg/dL: Gulu III, kwambiri: 2.0-4.0 mg/dL: Gulu IV, ndi kumapeto:> 4.0 mg/dL). Komabe, chifukwa cha kuchepa kwa mphamvu ya creatinine m'matenda a impso oyambirira (CKD), chizindikiro china choyambirira cha kusefera kwa nephron, "symmetric dimethylarginine (SDMA)", chinagwiritsidwa ntchito. Malinga ndi kafukufukuyu, SDMA imatha kuwonetsa zolakwika pa 25-40% ya kuwonongeka kwaimpso, pomwe creatinine nthawi zambiri imawonedwa ngati yachilendo pa 75% ya kuwonongeka.
CysC (cystatin C) ndi cysteine protease inhibitor, kulemera kochepa kwa molekyulu (13.3 kD), mapuloteni osakhala a glycosylated. Ndi chimodzi mwazizindikiro zomwe zimagwiritsidwa ntchito kwambiri poyambira ntchito yaimpso m'mankhwala amunthu. Monga creatinine ndi SDMA, imasefedwa kudzera mu glomerulus, koma imasiyana ndi creatinine ndi SDMA chifukwa kagayidwe kake sikudutsa mkodzo wa mkodzo, koma pafupifupi kwathunthu zimapukusidwa ndi reabsorption kudzera aimpso tubules. Sizinawonekere kale, zomwe zimatsogolera akatswiri ambiri, akatswiri ndi mabuku kuti azitsatira mfundo ziwiri zosiyana za kuvulala kwa impso kwa amphaka: ena amakhulupirira kuti CysC ndi chizindikiro choyambirira cha kuvulala kwa impso kosatha komwe kungagwiritsidwe ntchito mwa agalu ndi amphaka, pomwe ena amakhulupirira kuti CysC imagwirizana bwino mu canine CKD, koma molakwika mwa amphaka.
Chifukwa chiyani pali ziganizo ziwiri zosiyana kuchokera ku "glomerular filtration function index" yomweyo?
Chifukwa chake ndi Anuria, yomwe imakhala yofala kwambiri mwa amphaka kusiyana ndi mitundu ina, makamaka amphaka aamuna. Deta ina ikuwonetsa kuti kuchuluka kwa Anuria mwa amphaka aamuna ndi okwera kwambiri mpaka 68.6%, ndipo Anuria imatha kuyambitsa kutsekeka kwa creatinine, urea wa nayitrogeni wamagazi ndi SDMA. Chamoyocho chimagwira ntchito nthawi zonse ndikupanga creatinine yatsopano, magazi urea nayitrogeni ndi SDMA, pozindikira zizindikiro zonse zitatu m'magazi panthawiyi, padzakhala kuwonjezeka kwakukulu kapena ngakhale kuphulika kwa zizindikiro ziribe kanthu kuti glomerulus yawonongekadi.
CysC ili ndi mtengo wake wapadera panthawiyi, ngakhale kuti chizindikiro ichi ndi kusefera kwa glomerular, sikumapangidwa ndi mkodzo, ndi kudzera mu tubular kuti iwonongeke. Anuria ikachitika koma ntchito yaimpso ndi yabwinobwino, index ya CysC imatha kusungidwa pamlingo wabwinobwino. Pokhapokha kuwonongeka kwa glomerulus kapena tubular kumachitika, index ya CysC imakwezedwa kukhala yachilendo. Chifukwa chake, kuzindikira ma index onse atatu kumatha kuzindikiritsa molondola komanso kupereka chithandizo choyenera mwachangu komanso moyenera.
Zatsopano zoyesa aimpso zoyeserera 3-in-1 zimapatsa chidziwitso chatsopano pakuzindikira kuvulala kwa aimpso mwa agalu ndi amphaka!
Pofotokoza mfundozo ndikuphatikiza ndi mawonekedwe azizindikiro, zida zoyeserera za New-Test renal function marker 3-in-1 zidabadwa ndi kufunikira kwachipatala kwa agalu ndi amphaka (makamaka amphaka) ndi Anuria:
Zida zoyezera aimpso zatsopano 3-in-1 zimagwiritsidwa ntchito kusiyanitsa ngati pali vuto lenileni la aimpso mu chikhalidwe cha Anuria kapena zomwe zimapangitsa kuti ma index atsekeke chifukwa cha Anuria. Kuvulala kwenikweni kwa aimpso kumafuna catheterization ya mkodzo kokha ndi chisamaliro chofananira, ndipo kuzindikirika kwake kumakhala bwinoko. Kutsekeka kwa ma index kumafuna osati kokha catheterization ya mkodzo ndi mankhwala odana ndi kutupa, komanso chithandizo chokhudzana ndi matenda a aimpso, ndipo matendawa ndi ovuta, ndipo amatha kukhala matenda aakulu a impso.
Pansipa pali chidziwitso cha New-Test renal function marker 3-in-1 test kits ya Anuria (Kuvulala kopanda impso kwenikweni) ndi Anuria + kuvulala kwa impso muzochitika zofufuza zachipatala za New-Test:
| Kuzindikira kwa Anuria Mayeso atsopano a renal function marker 3-in-1 test kits | Ntchito | Zotsatira | Zotsatira |
| Creatinine | + | + | |
| SDMA | + | + | |
| CysC | + | - | |
| Mapeto | Anuria yachititsa kuvulala kwa aimpso | Kumayambiriro kwa Anuria ndi kuvulala kwaimpso kapena Anuria komwe sikunafike kuvulala kwaimpso |
Pansipa pali gawo lazachipatala komanso kufotokozera kwa New-Test renal function 3-in-1 test kits:
| Mphaka | Mbiri Yachipatala | Zizindikiro Zachipatala | CysC(mg/L) | SDHA (ug/dL) | CR(mg/dL) | Mapeto |
| 2024090902 | Cystitis / Kuvulala kwakukulu kwa aimpso | Kusokonezeka kwamalingaliro, Kutaya chilakolako cha chakudya, Kulephera kwa aimpso, Anuria (Kulephera kwaimpso, anuria) | 1.09 | 86.47 | 8.18 | Kuvulala kwa aimpso ndi Anuria |
| 2024091201 | / | Kuipa kwamaganizidwe, Anuria, Kulephera kwaimpso | 0.51 | 27.44 | 8.21 | Palibe kuvulala aimpso ndi Anuria/Early stage |
| 2024092702 | / | Anuria | 0.31 | > 100.00 | 9.04 | Palibe kuvulala aimpso ndi Anuria/Early stage |
| 2024103101 | / | Anuria | 0.3 | 14.11 | 6.52 | Palibe kuvulala aimpso ndi Anuria/Early stage |
| 2024112712 | Anuria | 0.5 | > 100.00 | 8.85 | Palibe kuvulala aimpso ndi Anuria/Early stage | |
| 2024112601 | Dysuria/Anuria | 0.43 | > 100.00 | 9.06 | Palibe kuvulala aimpso ndi Anuria/Early stage | |
| 0.47 | > 100.00 | 878 | Palibe kuvulala aimpso ndi Anuria/Early stage | |||
| 2024112712 | / | Anuria | 0.54 | 94.03 | 8.64 | Palibe kuvulala aimpso ndi Anuria/Early stage |
Mu chikhalidwe cha Anuria, chifukwa kusiyana mkati kagayidwe kachakudya limagwirira aliyense index, padzakhala chifukwa chachikulu kusiyana kwa yemweyo aimpso kusefera index. Choncho, magulu ochiritsira aimpso kuvulala kwa creatinine kapena SDMA sikugwiranso ntchito, ndipo mapeto afupipafupi achipatala angapezeke mwa kuphatikiza kusanthula ndi chizindikiro china "CysC". Ndikofunikira kuti ma laboratories (zipatala) azikhazikitsa miyezo yamkati motengera zomwe zachitika kuchipatala, kuti afufuze zambiri komanso zatsopano zachipatala.
Pomaliza, New-Test Biotech akuyembekeza kuti nkhaniyi iponya njerwa kuti ikope yade, ndipo ikuyembekeza kuti akatswiri azachipatala aku China komanso opanga mankhwala azidziwitso apanga mankhwala ofunikira kwambiri ndikuthandizira madotolo ambiri azanyama kuti afike pamlingo wapamwamba kwambiri. dziko!
Zowonjezera: Kuvomerezedwa kwa Patent Application for Intellectual Property Protection
Nthawi yotumiza: Jan-22-2025
